Redox and Muscle Regeneration: Strategic role of Micro RNA

Dulak josef Oman Redox 2018

Prof. Józef Dulak from the Department of Medical Biotechnology at Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University (Krakow, Poland)   presented his study during Paris Redox 2018 and will join us in Oman to present presentation entitled "Redox and Muscle regeneration: strategic role of micro RNA".

 

Summary of Talk:

Skeletal muscles, unlike the heart, efficiently regenerate after the damage, providing there is not additional insult which aggravates the injury and impairs the regenerative capacity of the satellite cells, the bone fide skeletal muscle stem cells. Particularly, the muscle damage propagates in Duchenne muscular dystrophy, the incurable genetic disease affecting about 1:5000 boys due to the mutation in dystrophin gene resulting in total absence of this protein. Muscle damage is associated with inflammation which when well controlled is quickly resolved. Our recent studies indicate that heme oxygenase-1 (HO-1), a crucial anti-inflammatory protein, is the important regulator of muscle regeneration and satellite cells’ differentiation. Specifically, the proper regulation of microRNAs biogenesis, and particularly the HO-1 effect on myomiRs involved in satellite cells differentiation is  prerequisite for the effective muscle repair. Interestingly, also other microRNAs, particularly involved in regulation of metabolism, appear to be significant for muscle regeneration. Overall, our data indicate the strategic role of microRNAs in muscle regeneration with the proper redox control being the crucial part of reparative machinery. 

 

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